ea0015oc2 | Young Endocrinologist prize session | SFEBES2008
Amin Faisal
, Kola Blerina
, Christ-Crain Mirjam
, Lolli Francesca
, Wittmann Gabor
, Harvey-White Judith
, Kunos George
, Grossman Ashley B
, Fekete Csaba
, Korbonits Marta
We have previously shown that the orexigenic and peripheral adipogenic effects of ghrelin are mediated by its effect on the metabolic enzyme AMPK. As the cannabinoid (CB1)-antagonist rimonabant inhibits the orexigenic effect of ghrelin, we suggest that there is an interaction between cannabinoids and ghrelin.To study the involvement of CB1 in the effects of ghrelin, wild-type (WT) and CB1-knockout mice were treated with ghrelin and rimonabant.<p clas...